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Low Testosterone or ED — Which Comes First? A Guide for Men Over 40

Reviewed on 26 Aug 20269 min read
Dr Zaenab Al-zubaidiMedically reviewed byDr Zaenab Al-zubaidi
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Key Takeaways

  • Low testosterone and erectile dysfunction (ED) are two separate health issues that have a lot of connection with each other, but that doesn't mean one necessarily causes the other.
  • Testosterone is responsible for libido, but ED is a problem of blood circulation and nerve signaling; hence, one can experience either of them separately.
  • Studies show that there is some overlap between testosterone levels and erectile dysfunction, but it is not too significant: according to studies, depending on the findings, about 2-40% of men suffering from ED also have low testosterone levels.
  • The great majority of ED cases, even in men older than 40, occur in men with normal testosterone levels since most cases of ED are caused by vascular, metabolic, and lifestyle factors.
  • They have common risk factors, which is another reason why they often occur together in men who have issues with both hormone and sexual functions.
  • In order to diagnose, physicians have to take blood tests, rather than give guesses just relying on symptoms.
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At 40, you may experience some alarming new developments: less energy, a diminished libido, or an erection that seems to falter at will. It’s natural to blame it all on the same culprit if it happens seemingly all at once: a decline in testosterone levels. Indeed, according to studies on aging men, you are most likely experiencing sex organs at this point to be affected by vascular diseases, nerve problems in the nervous system, and hormonal imbalances such as those caused by low testosterone.

Though the role of testosterone in male sexual function may or may not be the primary factor, but what is for sure is that every physical occurrence resulting from aging in men can be attributed to this hormone.

In fact, in correcting the first aspect of your issue you might not be able to get rid of the secondary issue that is caused by various other additional factors. Here, in this article, Direct Meds analyze to clarify the given contradiction and explain exactly how doctors can work out the situation as well as how low testosterone could serve as both acute cause and consequence of ED.

What's the Difference Between Low Testosterone and ED?

Testosterone is typically referred to as the "want to" hormone because it is mainly produced in the testes and has an important impact on libido, muscle mass, bone density, energy, and mood. When the hormone levels go down, a man might lose interest in sex, feel perpetually tired, or have mood fluctuations that can occur even if the man has the ability to have an erection.

On the other hand, erectile dysfunction is a mechanical, vascular "can I" issue rather than a "want to" issue. An erection requires a good state of blood vessels that should widen, nerves that need to send the appropriate signal, and blood kept in the tissue of the penis long enough to achieve rigidity.

This distinction is significant because you may want sex and not have the ability to perform, (classic ED with normal testosterone), or you may not want sex even if you are able to perform under some conditions (classic low testosterone without ED).

Recent-onset testosterone deficiency among middle-aged males is on rise and can also impact obesity, sleep apnoea and metabolic syndrome.

According to research estimates in the range of 6–12% 40-aged males present biochemical lower testosterone levels. Half of 40+ aged guys is a mixture of these two, which is why trying to separate them makes all distinction with the purpose of you can obtain the proper therapies.

Low Testosterone or ED — Which Comes First A Guide for Men Over 40

Can Low Testosterone Have an Effect on Erectile Dysfunction?

Lowered levels do create ED worse: However testosterone inadequacy could contribute to ED, it hardly never appears in isolation. Testosterone deficiency is associated to erectile dysfunction . It performs true biological roles when it comes to regulating the process that helps trigger the physiological part on penile structures,which makes the PDE5 inhibitors (sildenafil & tadalafil take their effects . The impact appears to result in decreased physical ability for any body structure but blood streams will stay working efficiently .

However, the degree of correlation of Low testosterone and ED with respect to numerous reports seems to differ substantially, depending on methodology employed to calculate plasma testosterone and populations of sex and years of age examined.

Can Erectile Dysfunction Happen With Normal Testosterone?

Yes; in fact, this is the case for most men suffering from erectile dysfunction. According to study, approximately 40% of men experience erectile dysfunction at age 40, and this number jumps to as much as 70% in men by age 70; meanwhile, low testosterone (hypogonadism) is present in a smaller percentage of men, often estimated at between 10% of the older male population and 40%, depending on the population and definition used in the research. Since it is more common for men to suffer from erectile dysfunction than have low testosterone, it is possible for men to experience erectile issues at normal hormonal levels.

In such cases, the cause of the problem is much more likely to be vascular diseases (caused by restricted blood flow due to narrowed arteries), diabetes, high blood pressure, some medications, smoking, obesity, or causing issues like stress, anxiety, and depression. Because of this factor, specialists are now treating all cases of new erectile dysfunction as possible preliminary signs of cardiovascular diseases.

Common Risk Factors: Understanding the Reasons for the Connection between the Two Conditions

The relationship between low testosterone levels and erectile dysfunction is not based purely on coincidence, since the two conditions appear to occur at the same time due to the fact that a number of diseases damage both testosterone-producing mechanism and the mechanisms required to create an erection independently from the other condition.

  • Overweight and Metabolic Syndrome: Excess body mass, especially abdominal fat, causes low testosterone levels as well as problems with blood vessels which play an important role in creating an erection; thus, the two systems suffer from the condition simultaneously.
  • Diabetes: High blood sugar levels destroy blood vessels and nerves in the entire body, being one of the major factors of vascular erectile dysfunction as well as being connected to low testosterone levels.
  • Heart Disorders and High Blood Pressure: Unhealthy heart condition leads to not good blood circulation in every part of the body including the penis and medications for high blood pressure sometimes have the side effect of erectile dysfunction, increasing the chances of a man having both problems.
  • Aging: With getting older human beings proceed with a decrease in both their average testosterone level and the ability to achieve an erection; thus, merely due to aging, these two processes occur at the same time even if there is no direct connection between them.

The fact that some risk factors contribute to weakening of both hormonal and vascular systems means that the treatment of only one of them, for instance, stimulating testosterone without addressing some underlying causes of the problem like being overweight or the presence of diabetes or high blood pressure usually brings neither effective nor desired results.

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Does Anything Change?: The Two-Way Relationship

At the same time, the studies demonstrate to us that the relationship can be bilateral and not only unidirectional. Ultimately, chronic ED can lead to problems with sleep, stress, and impaired physical activity, which in the long run can lead to testosterone production dropping. Meanwhile, low levels of testosterone usually lead to a lack of motivation for physical activity and consequently to gaining extra weight, which decreases vascular health and raises ED risk. This is the reason why a lot of men become trapped in this situation.

How Physicians Really Determine What You Are Affected By

Self-diagnosis relying entirely on symptoms is not sufficient because of the factors described above; hence, it is difficult to differentiate between the two cases. The diagnosis process comprises a number of steps:

  • Tests for total and free testosterone, which are to be done in the morning (7-10 am) - the time when testosterone levels are the highest; the test can be repeated to reconfirm a low reading,
  • Completion of questionnaires concerning the severity of erectile dysfunction symptoms like the International Index of Erectile Function (IIEF-5).
  • Evaluation of medical history and prescriptions since several conditions like diabetes or high blood pressure as well as some medications may lead to ED.
  • Conducting further tests depending on the situation (blood tests to check blood sugar and cholesterol levels or for cardiovascular assessment of men over 40 years suffering from newly appeared ED).

This is the reason why it's crucial to consult a health professional, instead of doing an educated guess: two patients with the same symptoms could have completely different reasons for their condition, and as a result, they would need different treatments.

Low Testosterone or ED — Which Comes First A Guide for Men Over 40

Treatment: The Major Idea of Flexibility

After the cause of the problem is determined and clear, it can be divided in different categories:

If Low Testosterone is Proved

Usually, if testosterone levels are confirmed to be low, TRT, using gels, injectables or patches is an adequate remedy. It can raise libido, energy and spirits, as well as improve some aspects of erectile function for men diagnosed with this condition. There are also many studies demonstrating that the trials involving testosterone for ED mostly resulted in contradictory outcomes. There are also guidelines stating that testosterone supplementation is not enough and in most cases combination with PDE5 inhibitors have to be used.

If ED is Present with Normal Testosterone

PDE5 inhibitors remain the recommended first line therapy in all cases regardless of other underlying conditions.

When Both Factors Are Present

In a combination therapy, individuals have been found to exhibit best results with findings supporting that male individuals who underwent both testosterone treatment and PDE5 inhibitor therapy have reported significant improvement in erectile function as compared to PDE5 inhibitor medication alone, especially when the patients were found to have poor responses to the PDE5 inhibitor therapy alone.

As a result of such findings, it is now recommended in the guidelines of therapy that this specific combination of therapy should be used in the case of patients whose testosterone levels have been diagnosed as low and their erectile dysfunction did not respond satisfactorily to medications used.

How Lifestyle Changes Can Facilitate Healing of Both Conditions

Due to the fact that obesity, poor cardiovascular health and metabolic disorders are often associated with both the situation of low testosterone and erectile dysfunction, the following lifestyle changes can actually present benefits to both issues and bring positive results:

  • Getting rid of unnecessary body weight, especially fat on the stomach, since this process both contributes to testosterone synthesis and a healthy blood flow.
  • Exercising regularly, especially during weight lifting and aerobic activities, which ensures improvement in testosterone levels and blood
  • Improving sleep quality and treating sleep apnea when suspected since testosterone production is affected by deep sleep
  • Reducing alcohol consumption and giving up smoking; both actions affect blood vessels and testosterone.
  • Controlling blood pressure, blood glucose, and cholesterol levels through diet and medicines if needed.

Low Testosterone or ED — Which Comes First A Guide for Men Over 40

At What Point Should One Consult a Doctor?

If low libido occurs alongside impotence regularly, it’s advisable to schedule a private consultation.

  • You should consult a doctor if you suffer from constant low libido and impotence because of erectile dysfunction, if impotence has an abrupt onset, or if you experience excessive tiredness, mood swings, and weight gain that may suggest problems in the field of hormones.
  • Since this condition can indicate heart disease or diabetes, it’s necessary to be properly diagnosed instead of saying “It is just age” or trying to treat the condition with vitamins and guessing.

Access Support via DirectMeds

Deciding if low testosterone, ED, or both of these is causing the symptoms you’re experiencing is not a mystery you need to solve on your own.

  • DirectMeds is a trusted AHPRA-registered Australian telehealth service to get to the root of the issue with medical certainty
  • Complete the confidential, free online health assessment.
  • Talk with an AHPRA-registered doctor about any libido concerns and erectile health issues you are experiencing.

Instead, have the correct tests or specialist referrals booked by a medical professional. Receive an individually tailored plan and access medication approval.

Frequently Asked Questions for Low Testosterone and ED:

How does low testosterone cause ED?

Hormones control processes in the penis related to nitric oxide (which relaxes the blood vessels and enables sufficient blood flow) and the smooth muscle tissues that support this process. Yet evidence suggests that for the 2 to 40% of ED patients with low testosterone, it’s either very low – not just somewhat low – but this depends on which testing mechanism is used.

Can you suffer from ED even if your testosterone levels are perfectly normal?

For the vast majority of individuals who experience ED – 60 to 98 percent, most of them men – it's caused by factors like cardiovascular disease, diabetes, smoking, or high blood pressure, none of which are influenced in any way by the presence of adequate hormone levels. Therefore, perfectly fine hormone concentrations do nothing to guarantee that your sexual experiences will remain unimpeded.

What are the signs of low testosterone in men over 40?

Symptoms like low sex drive, ongoing fatigue, loss of muscle, weight gain, low mood or irritability, and lack of morning erections can be seen. A blood test can confirm testosterone deficiency, rather than relying on symptoms alone.

Is testosterone replacement therapy a cure for ED?

Generally, it can only help ED if testosterone is in fact truly low, as generally guidelines do not recommend it as a treatment alone, only combination therapy (TRT with PDE5 inhibitors) is recommended as a therapy with PDE5 inhibitors for definite hypogonadal men.

How is low testosterone diagnosed?

With a morning blood test to measure total and free testosterone (which is ideally verified on another day), and will consider symptoms, other illness, and medications prescribed before diagnosis.

Should I have my testosterone level tested if I have ED?

Urological guidelines generally advise that all ED patients have their testosterone levels tested, as identifying testosterone deficiency will have a definite treatment consequence, and is more important if ED medication is not working sufficiently by itself.

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